|Pharmacology and Toxicology|
The laboratories in the department are working in the areas of cell biology, biochemistry, immunology, molecular biology, microbiology, parasitology, cell culture, and membrane drug interaction. The department is actively pursuing research in the following areas.
The department is engaged in the following areas of research
Identification and validation of novel target sites for various therapeutic areas: Design and synthesis of new chemical entities as anticancer, antileishmanial, broad-spectrum antimalarial, antituberculosis, antihypertensive, antiinflammatory, antidiabatic, anti-viral compounds and multi-drug resistance reversal agents.
Asymmetric Synthesis: Development of methodologies for catalytic asymmetric synthesis-dynamic kinetic resolution, asymmetric protonation/ deprotonation, asymmetric epoxidation, asymmetric aziridation and asymmetric alkylation. Synthesis of chiral drugs .
Combinatorial Chemistry: Development of novel linkers and analytical protocols; generation of molecular libraries.
Peptide Synthesis: Synthesis of unnatural amino acids and their incorporation in the peptides of biological importance by using solution- and solid- phase synthesis protocols. Receptor binding studies on the TRH peptides.
Eco-friendly Processes: Development of new methodologies under solvent free condition, surface mediated reactions, microwave/ ultrasound assisted enhancement of reaction rates. Development of heterogeniuos catalysts. Use of ionic liquids as organo-catalysts- mechanistic investigation for rational design. Use of non-conventional reaction media- reaction in eater with or without any catalytic aid, mechanistic investigation of water catalysis for rational selection of newer reaction in water. Applications of the novel methods for synthesis of drugs, drug intermediates and new chemical entities for various therapeutic areas.
Computer Aided Drug Design: Molecular modeling methods based on molecular mechanics, Quantum mechanics. Analog based design of - Kinase, Phosphatase, Protease, HMG-CoA reductase, selective COX-2, selective PDE4 inhibitors and hemaglutinin of H1N1 virus. PPAR- g and Angiotensin receptor antagonist, Alzeimer dementia by 3D-QSAR, CoMFA, and docking methods.
Design and synthesis of PPARg agents. 3D QSAR, pharmacophore mapping, virtual screening, molecular docking, de novo design of novel agents for PPARg activity. Computer aided design of GSK3 inhibitors. Quantum chemical studies on the anti-diabetic drugs and leads -- sulfonylurea derivatives, DPPIV inhibitors, metformin analogs.
Design and synthesis of anti-malarial agents: Quantum chemical methods in analyzing the reaction mechanism of synthesis of GTU (Guanylthiourea) derivatives as anti-malarial agents. Synthesis of GTU derivatives for PfDHFR inhibition. Quantum chemical analysis of proguanil to cycloguanil conversion. Ab initio studies on the biurets, thiobiurets, etc. analogs of pyrimethamine.
Computational design of novel dedrimers units for anti-diabetic agent.
Computational prediction of SOM of substrates by Cytochromes.
Molecular Dynamic simulations (quantum as well as force field) to understand basics of drug action.
The departmental research activities are concentrated in the following areas:
1. Discovery of new chemical entities (NCEs) from natural products of terrestrial, microbial and marine origin in the following therapeutic areas:
2. Traditional Medicine development programmes: Standardization and quality control of herbal drugs and products.
3. Process technology programmes: Development of chemical process technologies for important natural products involving isolation, semisynthesis or synthesis.
4. Other areas of interest:
The department is involved in the diversified activities, including active
involvement in industrial research projects. The key areas of research are:
|ADME QPrOmics Database (Department of Pharmaceutical Analysis in collaboration with University of Washington, USA is developing a data module of database named QPrOmics™ which is a Knowledge base crafted for enthusiasts and researchers pursuing the field of drug pharmacokinetics (PK) and pharmacodynamic (PD) and pharmacometricians in the drug development industry, regulatory and academia.)|
|List of Reference Standards Supplied by the Department of Pharmaceutical Analysis uploaded on 15-Jan-2019|
A recent diversified expansion of the Institute is the Department of Pharmaceutical Management which has been created with a view to provide a specialized, high quality education as preparation for professional positions in pharmaceutical business and industry. The objectives of this course are to teach pharmaceutical management to the Pharmacy graduates to become the successful managers in pharmaceutical industry by applying the fundamentals of management. The department is actively engaged in Teaching, Research and Training and Development programmes related to the following:
A. Process Chemistry
A special feature of the Institute is the Department of Pharmaceutical Technology which has been created with a view to directly interact with industry. The department has a pilot plant associated with it for pilot-scale processing of bulk drugs and natural products. The department has build up facilities for scale up studies during development of technologies for bulk pharmaceutical chemicals and different dosage forms. The department is actively engaged and can collaborate in projects related to the following.
Processes for the following APIs are available for licensing and other projects that have been completed:
The biotechnology unit of Pharmaceutical Technological Department has been set up with a view to create awareness in the field of pharmaceutical biotechnology. Biotechnology being an interdisciplinary subject and NIPER being an pharmaceutical institute, pharmaceutical biotechnology was thought to be an appropriate subject of teaching and research in this department. The main objective is to pertain training to the students on the different aspects of pharmaceutical biotechnology such as production of high value products though high cell density fermentation, to produce active intermediates through biocatalysis, downstream processing of biomolecules, etc. The unit has taken the initiative to start research activities in the field of biocatalysis to produce enantiomerically pure isomers intended to use as drugs and drug intermediates. The unit runs a full fledged M.Tech. programme in pharmaceutical biotechnology sponsored by the Department of Biotechnology (Govt. of India). The following projects are currently going on
Department of Pharmacology and Toxicology has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas:
Drug development has become increasingly complex, time consuming and expensive. As a result there is an increased focus on making clinically established drugs perform better therapeutically in terms of efficacy, safety and improved patient compliance by designing novel and patentable technologies or delivery systems. This has led to a paradigm shift in drug delivery technologies from conventional dosage forms to controlled release and sophisticated delivery systems. These systems are based on the concepts of biopharmaceutics and pharmacokinetic driven by pharmacodynamic activity and therapeutic needs. The emergence of the Biopharmaceutic Classification System (BCS) based on the two tenets of absorption namely solubility and permeability has further simplified drug development program form a regulatory perspective. About 20 drugs, which are not only of clinical significance but also, model drugs representing various classes were chosen by the department to carry out research and projects in the area of conventional and novel drug delivery systems, biopharmaceutics and pharmacokinetic evaluation, bioavailability and bioequivalence testing, preformulation, formulation development and stability testing.
The department of pharmaceutics is one of the key departments of the Institute. It is equipped with state of the art facilities to undertake research in drug development and delivery. More recently, the department has initiated research on Biomaterials and Nanotechnology. In the frontier area of Biomaterial research, the focus will be for synthesis and characterization of new biodegradable polymer, their formulations for various drug delivery systems, to improve surface biocompatibility of medical devices and their invitro/invivo evaluation. To strengthen our research potential, nanotechnolgy will be utilized to prepare effective carriers to deliver the drugs at diseases targets and effort will be taken to initiate gene delivery program in our department.
The department is presently engaged in research projects on:
In 2002, a new course leading to the award of M. Pharm. (Pharmacy Practice) was started at NIPER, SAS Nagar. The three core areas identified for this department are Clinical, Hospital and Community Pharmacy. In a very short span of time, the department has made significant progress and has been able to evolve on the first two areas by developing a strong interface with three major hospitals in the region.
One of the missions of the department is to provide quality-teaching programs
that will prepare the students for entry into all areas of professional pharmacy
Currently, the emphasis is placed on principles of pharmacotherapy and practice management for the purpose of advancing quality cost-effective pharmaceutical care. The Department of Pharmacy Practice is committed to:
The department intends to grow into the following areas and looks forward to collaborate with external agencies
In 2011, another new course leading to M.Pharm. (Clinical Research) was started and the department was entrusted to run this course. Upon successful completion of this course, the students are geared to get into any functional area of clinical research. They receive intensive training in medical writing, documentation, clinical data management, project management and complete a six-month project too.
For any further queries about these programs, please feel free to contact Prof. Pramil Tiwari, Professor & Head of the department through e-mail email@example.com.
discovery research has become much more complex science requiring a multidisciplinary
approach. Converging concepts of several disciplines such as molecular
biology, chemistry, toxicology, pharmaceutical sciences and computational
technology has become more than a trend in education. It has become a
necessity for solving real-world problems. This course is designed to
teach the new millennium drug discovery science to the pharmacy graduates
to become the successful drug discovery scientist in pharmaceutical industry.
The objectives are,
In order to keep pharmacy professionals acquainted with the latest developments
in the field of pharmacy, the institute conducts training programs from
time to time. NIPER has been empanelled by Ministry of External Affairs,
Government of India to conduct training programs on regulatory aspects
in pharmaceutical sciences for the international delegations and also
by Ministry of Health to conduct training programs for drug regulatory
staff, government analysts and technical and analytical staff from SSIs.
The institute can provide specialized training in the following areas:
In order to keep pharmacy professionals acquainted with the latest developments in the field of pharmacy, the institute conducts training programs from time to time. NIPER has been empanelled by Ministry of External Affairs, Government of India to conduct training programs on regulatory aspects in pharmaceutical sciences for the international delegations and also by Ministry of Health to conduct training programs for drug regulatory staff, government analysts and technical and analytical staff from SSIs. The institute can provide specialized training in the following areas:
Page Last Updated / Reviewed on: 14-February-2019